In Vitro Toxicity Testing

 

Bone Marrow Toxicity/Stem Cell Hematotoxicity

 

Preferred Cell Systems™ offers the largest selection of assays to detect bone marrow toxicity. These include colony-forming cell (CFC) assays that are used to determine effects on differentiation and maturation response to drugs and other agents. 

However, the majority of drugs and other agents interfere with the proliferation process, rather than the differentiation of cells.

Specifically designed for bone marrow toxicity and stem cell hematotoxicity, in particular, HALO®-Tox HT is the most advanced and reliable toxicity assay platform validated for this purpose. Available in both 96-well and 384-well plate formats, HALO®-Tox HT is a complete, ready to use, standardized assay platform. Measure cytotoxicity of individual stem or progenitor cell populations or use our "global" hematotoxicity assays to detect cytotoxicity to 4-, 5- or 7-populations simultaneously. In addition, HALO®-Tox HT is available for 5 human, primate, dog, rat and mouse.

We guarantee all of our products. Getting the highest quality results for your research is our goal. That includes providing excellent technical assistance. Contact us with your questions and feedback: (719) 264-6251 or info@preferred-cell-systems.com.

For contract research services, please contact HemoGenix® at info@hemogenix.com or call (719) 264-6250.

Our line of hematopoietic assays can be accessed here.

Immunotoxicity

 

Preferred Cell Systems™ immunotoxicity assays are complete and standardized ATP bioluminescence assays that allow the flexibility to use any immune growth medium and factors the investigator requires. Available in 96-well or 384-well plate formats, ImmunoGlo™-Tox HT assays are designed for high throughput screening or any other stage of drug development. Whether you use fresh or cryopreserved, peripheral blood mononuclear cells (PBMC), purified sub-populations or lymphoid cell lines, ImmunoGlo™-Tox HT is the assay of choice.  

ImmunoGlo™ TCP assays include co-stimulators for T-lymphocytes, and new assays are being developed for B-lymphocytes.

We guarantee all of our products. Getting the highest quality results for your research is our goal. That includes providing excellent technical assistance. Contact us with your questions and feedback: (719) 264-6251 or info@preferred-cell-systems.com.

For immunotoxicity contract research services, please contact HemoGenix® at info@hemogenix.com or call (719) 264-6250.

Our line of immune assays can be accessed here.

Hepatotoxicity

 

HepatoGlo™-Tox HT assays are part of the Preferred Cell Systems™ toxicity assay portfolio. Available as 96-well or 384-well plate assay kits, HepatoGlo™-Tox HT assays are complete and fully standardized test kits that can be used either with your own growth and maintenance medium or with that supplied in the kit. Regardless of whether you are using fresh, primary or cryopreserved hepatocytes, hepatocytes from species other than human, or hepatocyte cell lines, HepatoGlo™-Tox HT is the assay of choice. 
Our hepatotoxicity assays can be accessed here.

Mesenchymal Cell System Toxicity

 

The mesenchymal cell system is essential for ensuring normal hematopoietic function, as well as being capable of differentiating into osteoblasts, adipcytes or chondrocytes to name but a few. It follows that damage to the mesenchymal cell systems can have dramatic side effects. These can be predicted using MSCGlo™-Tox HT.

The MSCGlo™-Tox HT platform is a 96-well or 384-well plate, high throughput testing assay for mesenchymal stem cells derived from different species and sources, including ES- or iPS-derived MSCs. 

Our line of mesenchymal cell assays can be accessed here.

Neurotoxicity

 

NeuroGlo™-Tox HT is available as a complete assay with cryopreserved ES-derived neural or neuronal cells. Alternatively, the assay is available without cells allowing the investigator to use their own cell source from any species including transformed cell lines and tumor cells.

Like other Tox HT assays from Preferred Cell Systems™, NeuroGlo™-Tox HT incorporates a fully standardized ATP bioluminescence readout for accurate and reliable toxicity testing.

Our line of neural cell assays can be accessed here.

Primary Cells, ES, iPS, Cell Lines, Tumor Cells

 

To accommodate this large array of different cell types, Preferred Cell Systems™ offers STEMGlo™-Tox HT, a highly flexible toxicity testing platform for adherent or non-adherent cell types from multiple species. With the flexibility to use virtually any growth medium and protocol the investigator desires, STEMGlo™-Tox HT provides the perfect platform for studying the response of multiple cell types to drugs, xenobiotics and other agents.

Our line of progenitor cell assays can be accessed here.